- Sandwich Shop Restaurants, Fleming Island
- Satellite Dish Antennas & Equipment Dealers, Fleming Island
- Satellite Technology & Space Research, Fleming Island
- Satellite TV Service, Fleming Island
- School - Christian, Fleming Island
- Seafood Restaurants, Fleming Island
- Security Alarm Systems - Home & Business, Fleming Island
- Security Brokers & Dealers, Fleming Island
- Security Control Systems & Monitoring, Fleming Island - Polygraph, Lie Detector, CCTV, Fire Sensor Equipment, Etc
- Security Services, Fleming Island
- Shopping & Shopping Services, Fleming Island
- Silkscreen Printing, Fleming Island
- Skin Care & Cosmetology Salons, Fleming Island
- Skin Care Products & Treatments, Fleming Island
- Small Appliances, Fleming Island
- Snacks & Desserts, Fleming Island
- Social Services & Welfare, Fleming Island
- Societies & Foundation Associations, Fleming Island
- Special Interest Schools Or Instruction, Fleming Island
- Specialty Animal Services, Fleming Island
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- Specialty Stores, Fleming Island
- Specialty Vehicle Rental & Leasing, Fleming Island
- Speech & Hearing Specialists, Fleming Island
- Speech & Language Therapy, Fleming Island
- Sporting Goods Stores, Fleming Island
- Staffing & Support Services, Fleming Island
- State Government, Fleming Island
- Steak House Restaurants, Fleming Island
- Steel Bar Sheet Strip Tube Etcetera Manufacturers, Fleming Island
- Steel Manufacturers, Fleming Island
- Stocks & Bond Brokers, Fleming Island
- Submarine Sandwich Restaurants, Fleming Island
- Support Services, Fleming Island
- Surgical Hospitals, Fleming Island - Surgical Centers
- Surveyor Services, Fleming Island - Surveying Service
- Surveyors, Fleming Island
- Sushi Restaurants, Fleming Island
- Swimming Pool, Sauna & Spa Contractors, Fleming Island
- Swimming Pools Contractors, Fleming Island - Install Inground - Above Ground Pools
- Swimming Pools Supplies, Equipment & Accessories, Fleming Island
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