- Safety Equipment & Supplies, Seffner
- Sandwich Shop Restaurants, Seffner
- Satellite & Cable TV Equipment & Systems, Seffner
- Savings Banks, Seffner
- Scrap & Waste Materials, Seffner
- Screen Printing, Seffner
- Secondary Schools, Seffner
- Security & Surveillance System & Equipment, Seffner
- Security Brokers & Dealers, Seffner
- Security Services, Seffner
- Septic Tank Installation & Repair, Seffner - Septic Systems
- Septic Tank Pumping & Cleaning, Seffner - Septic Systems
- Septic Tanks & Septic Systems Contractors, Seffner - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Septic Tanks & Systems, Seffner - Wholesale, Dealers & Suppliers
- Sewer & Drain Cleaning & Repair, Seffner - Drain Cleaner & Installation Services
- Shopping & Shopping Services, Seffner
- Shore, Lake & Pond Maintenance & Treatment, Seffner
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- Signs, Seffner
- Snack Foods, Seffner
- Social Services & Welfare, Seffner
- Societies & Foundation Associations, Seffner
- Southern Style Restaurants, Seffner
- Special Education & Care, Seffner
- Special Events & Party Supply Rental, Seffner
- Special Interest Schools Or Instruction, Seffner
- Specialty Animal Services, Seffner
- Specialty Communication Companies & Services, Seffner
- Specialty Stores, Seffner
- Sporting Goods Stores, Seffner
- Sports Bars & Lounges, Seffner
- Staffing & Support Services, Seffner
- Stevedoring Contractors, Seffner
- Stocks & Bond Brokers, Seffner
- Submarine Sandwich Restaurants, Seffner
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