- Obstetricians & Gynecologists, Zephyrhills - Ob-Gyn Doctors, Physicians & Surgeons (Obstetrics & Gynecology)
- Off Road Vehicles, Zephyrhills
- Off Road Vehicles Parts & Accessories, Zephyrhills
- Office Supplies, Equipment & Office Furniture Stores, Zephyrhills
- Oil & Gas Exploration & Development, Zephyrhills - Oil Field Exploration, Monitoring & Remediation
- Oil Change & Lubrication, Zephyrhills - Auto Oil & Quick Lube
- Oil Industry & Oil Field Equipment & Services, Zephyrhills - Oil Companies
- Ophthalmologists, Zephyrhills - Eye Doctors, Physicians & Surgeons (Ophthalmology)
- Optical Stores - Eyeglasses, Lenses & Sunglasses, Zephyrhills
- Opticians, Zephyrhills
- Optometrists, Zephyrhills - Eye Doctors, Physicians & Surgeons (Optometry)
- Organ Donation & Tissue Banks, Zephyrhills
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- Ornamental Nursery, Zephyrhills
- Ornamental Nursery Services, Zephyrhills
- Orthodontist, Zephyrhills - Teeth Straightening, Invisalign & Dental Braces
- Orthopedists, Zephyrhills - Orthopedic Surgery Doctors, Physicians & Surgeons
- Orthotics and Prosthetics, Zephyrhills
- Other Building Materials & Supplies, Zephyrhills
- Outdoor & Lawn & Garden Equipment Repair & Service, Zephyrhills
- Outdoor Equipment & Accessories, Zephyrhills
- Outdoor Furniture & Patio Furniture, Zephyrhills - Garden Furniture Stores
- Outpatient Services, Zephyrhills - Outpatient Care
- Oxygen & Respiratory Equipment & Supplies, Zephyrhills - Oxygen Concentrator, Tank, Machine, etc
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