- Safety Equipment & Supplies, Clewiston
- Salvation Army, Clewiston
- Sand Gravel & Aggregate, Clewiston
- Sandwich Shop Restaurants, Clewiston
- Satellite TV Service, Clewiston
- Screen Printing, Clewiston
- Seafood Restaurants, Clewiston
- Secondary Schools, Clewiston
- Security Alarm Systems - Home & Business, Clewiston
- Security Control Systems & Monitoring, Clewiston - Polygraph, Lie Detector, CCTV, Fire Sensor Equipment, Etc
- Security Investigative Services, Clewiston
- Security Services, Clewiston
- Sheriff's Department, Clewiston
- Shopping & Shopping Services, Clewiston
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- Signs, Clewiston
- Sleep Disorders Treatment & Information Centers, Clewiston
- Snack Foods, Clewiston
- Social Services & Welfare, Clewiston
- Societies & Foundation Associations, Clewiston
- Specialty Communication Companies & Services, Clewiston
- Specialty Stores, Clewiston
- Sporting & Recreational Camps, Clewiston
- Sporting Goods Stores, Clewiston
- Staffing & Support Services, Clewiston
- Submarine Sandwich Restaurants, Clewiston
- Sugar Refiners, Clewiston
- Surveyor Services, Clewiston - Surveying Service
- Swimming Pools Repair, Service, Supplies, Sale & Installation, Clewiston
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