- Obstetricians & Gynecologists, Leesburg - Ob-Gyn Doctors, Physicians & Surgeons (Obstetrics & Gynecology)
- Occupational Health Care Physicians & Surgeons, Leesburg - Occupational Medicine
- Occupational Health Care Professionals, Leesburg
- Occupational Medicine Doctors, Leesburg - Physicians & Surgeons
- Off Road Vehicles, Leesburg
- Off Road Vehicles Parts & Accessories, Leesburg
- Office Buildings & Parks, Leesburg
- Office Supplies, Equipment & Office Furniture Stores, Leesburg
- Oil & Gas Exploration & Development, Leesburg - Oil Field Exploration, Monitoring & Remediation
- Oil Change & Lubrication, Leesburg - Auto Oil & Quick Lube
- Oil Industry & Oil Field Equipment & Services, Leesburg - Oil Companies
- Oncologists, Leesburg - Cancer Doctors, Physicians & Surgeons (Oncology)
- Ophthalmologists, Leesburg - Eye Doctors, Physicians & Surgeons (Ophthalmology)
- Optical Goods Manufacturers, Leesburg
- Optical Goods Repair & Service, Leesburg - Camera Repair
- Optical Stores - Eyeglasses, Lenses & Sunglasses, Leesburg
- Opticians, Leesburg
- Optometrists, Leesburg - Eye Doctors, Physicians & Surgeons (Optometry)
- Oral Surgeon, Leesburg - Dentists - Oral & Maxillofacial Surgeons
- Orchid Growers, Leesburg
- Organs Tuning & Repair, Leesburg
- Oriental Food Products, Leesburg
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- Ornamental Nursery, Leesburg
- Ornamental Nursery Products, Leesburg
- Ornamental Nursery Services, Leesburg
- Orthodontist, Leesburg - Teeth Straightening, Invisalign & Dental Braces
- Orthopedic & Prosthetic Appliances & Shoes, Leesburg - Orthopedic Shoes
- Orthopedists, Leesburg - Orthopedic Surgery Doctors, Physicians & Surgeons
- Orthotics and Prosthetics, Leesburg
- Other Attorneys & Lawyers, Leesburg
- Other Attorneys & Lawyers, Leesburg
- Other Building Materials & Supplies, Leesburg
- Other Lawyers & Attorneys, Leesburg
- Other Lodging, Leesburg
- Outboard Motors, Leesburg
- Outboard Motors Parts & Repair, Leesburg
- Outdoor & Lawn & Garden Equipment Repair & Service, Leesburg
- Outdoor Advertising & Billboard, Leesburg
- Outdoor Equipment & Accessories, Leesburg
- Outdoor Furniture & Patio Furniture, Leesburg - Garden Furniture Stores
- Outpatient Services, Leesburg - Outpatient Care
- Ownership Organizations, Leesburg
- Oxygen & Respiratory Equipment & Supplies, Leesburg - Oxygen Concentrator, Tank, Machine, etc
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