- Sales & Marketing Consultant, Middleburg
- Salvage Disposal Service, Middleburg
- Salvation Army, Middleburg
- Sand Gravel & Aggregate, Middleburg
- Sandwich Shop Restaurants, Middleburg
- Savings Banks, Middleburg
- School - Catholic, Middleburg
- School - Christian, Middleburg
- Screen Printing, Middleburg
- Seafood Restaurants, Middleburg
- Secondary Schools, Middleburg
- Secretarial & Court Reporting Services, Middleburg
- Security & Commodity Brokers, Middleburg
- Security Alarm Systems - Home & Business, Middleburg
- Security Control Systems & Monitoring, Middleburg - Polygraph, Lie Detector, CCTV, Fire Sensor Equipment, Etc
- Security Services, Middleburg
- Senior Citizens Service & Health Organizations, Middleburg
- Septic Tank Pumping & Cleaning, Middleburg - Septic Systems
- Septic Tanks & Septic Systems Contractors, Middleburg - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Septic Tanks & Systems Inspection, Middleburg
- Sewer & Drain Cleaning & Repair, Middleburg - Drain Cleaner & Installation Services
- Sheriff's Department, Middleburg
- Shipping Companies, Middleburg
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- Shopping & Shopping Services, Middleburg
- Siding Contractors, Middleburg - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Signs, Middleburg
- Skating Supplies, Middleburg - Ice, Inline, Speed, Figure & Roller Skates
- Skin Care & Cosmetology Salons, Middleburg
- Skin Care Products & Treatments, Middleburg
- Social Clubs & Organizations, Middleburg
- Social Services & Welfare, Middleburg
- Special Interest Schools Or Instruction, Middleburg
- Specialty Animal Services, Middleburg
- Specialty Rental Services, Middleburg
- Specialty Stores, Middleburg
- Sporting Goods Stores, Middleburg
- Sports Bars & Lounges, Middleburg
- Staffing & Support Services, Middleburg
- Steel Erection Contractors, Middleburg - Steel Erectors
- Steel Manufacturers, Middleburg
- Storm Doors & Windows, Middleburg
- Submarine Sandwich Restaurants, Middleburg
- Surgical Supplies & Equipment, Middleburg
- Surveyor Services, Middleburg - Surveying Service
- Surveyors, Middleburg
- Swimming Pools Supplies, Equipment & Accessories, Middleburg
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