- Obstetricians & Gynecologists, Sanford - Ob-Gyn Doctors, Physicians & Surgeons (Obstetrics & Gynecology)
- Off Road Vehicles, Sanford
- Off Road Vehicles Parts & Accessories, Sanford
- Office Machinery, Sanford
- Office Supplies, Equipment & Office Furniture Stores, Sanford
- Oil & Gas Exploration & Development, Sanford - Oil Field Exploration, Monitoring & Remediation
- Oil & Petroleum Products, Sanford - Merchant, Wholesalers, etc
- Oil Change & Lubrication, Sanford - Auto Oil & Quick Lube
- Oil Industry & Oil Field Equipment & Services, Sanford - Oil Companies
- Ophthalmologists, Sanford - Eye Doctors, Physicians & Surgeons (Ophthalmology)
- Optical Stores - Eyeglasses, Lenses & Sunglasses, Sanford
- Opticians, Sanford
- Optometrists, Sanford - Eye Doctors, Physicians & Surgeons (Optometry)
- Optometry Clinics, Sanford - Eye Clinics
- Oral Surgeon, Sanford - Dentists - Oral & Maxillofacial Surgeons
- Organizing Services & Products – Household & Business, Sanford
- Ornamental Nursery, Sanford
- Ornamental Nursery Services, Sanford
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- Orthodontist, Sanford - Teeth Straightening, Invisalign & Dental Braces
- Orthopedic & Prosthetic Appliances & Shoes, Sanford - Orthopedic Shoes
- Orthopedists, Sanford - Orthopedic Surgery Doctors, Physicians & Surgeons
- Other Attorneys & Lawyers, Sanford
- Other Attorneys & Lawyers, Sanford
- Other Building Materials & Supplies, Sanford
- Other Industrial Contractors, Sanford
- Other Lawyers & Attorneys, Sanford
- Other Lodging, Sanford
- Outboard Motors, Sanford
- Outboard Motors Parts & Repair, Sanford
- Outdoor & Lawn & Garden Equipment Repair & Service, Sanford
- Outdoor Advertising & Billboard, Sanford
- Outdoor Equipment & Accessories, Sanford
- Outdoor Furniture & Patio Furniture, Sanford - Garden Furniture Stores
- Outerwear Stores, Sanford - Jackets, Sunglasses, Hats, Caps, Coats, Gloves & More
- Ownership Organizations, Sanford
- Oxygen & Respiratory Equipment & Supplies, Sanford - Oxygen Concentrator, Tank, Machine, etc
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