- Safety & Security Systems & Consultants, The Villages
- Sandwich Shop Restaurants, The Villages
- Savings Banks, The Villages
- Scrapbooks & Scrapbook Supplies, The Villages
- Seafood Restaurants, The Villages
- Secondary Schools, The Villages
- Security & Commodity Exchanges, The Villages
- Security Brokers & Dealers, The Villages
- Sheriff's Department, The Villages
- Shipping Companies, The Villages
- Shoe Stores, The Villages - Mens, Womens & Kids Shoes
- Shopping & Shopping Services, The Villages
- Sleep Doctors, The Villages - Specialists, Physicians & Surgeons (Sleep Medicine)
- Snacks & Desserts, The Villages
- Social Security Counselors & Representatives, The Villages
- Social Services & Welfare, The Villages
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- Societies & Foundation Associations, The Villages
- Specialty Stores, The Villages
- Speech & Hearing Specialists, The Villages
- Sporting Goods Stores, The Villages
- Sports & Recreational Services, The Villages
- Sports Medicine, The Villages - Doctors, Physicians & Surgeons
- Staffing & Support Services, The Villages
- Stamp Collecting & Coin Dealers , The Villages
- Stock & Bond Brokers & Dealers, The Villages
- Stocks & Bond Brokers, The Villages
- Storage & Closet Equipment Supplies & Materials, The Villages
- Surgical Appliances & Supplies Manufacturers, The Villages
- Surgical Hospitals, The Villages - Surgical Centers
- Swimming Pools Supplies, Equipment & Accessories, The Villages
- Swimwear & Accessories Shops, The Villages - Water Sports Equipment
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