- Obstetricians & Gynecologists, Crystal River - Ob-Gyn Doctors, Physicians & Surgeons (Obstetrics & Gynecology)
- Occupational Health Care Professionals, Crystal River
- Occupational Therapy, Crystal River - Occupational Health Specialists
- Office Supplies, Equipment & Office Furniture Stores, Crystal River
- Oil Change & Lubrication, Crystal River - Auto Oil & Quick Lube
- Oncologists, Crystal River - Cancer Doctors, Physicians & Surgeons (Oncology)
- Ophthalmologists, Crystal River - Eye Doctors, Physicians & Surgeons (Ophthalmology)
- Optical Stores - Eyeglasses, Lenses & Sunglasses, Crystal River
- Opticians, Crystal River
- Optometrists, Crystal River - Eye Doctors, Physicians & Surgeons (Optometry)
- Optometry Clinics, Crystal River - Eye Clinics
- Oral Surgeon, Crystal River - Dentists - Oral & Maxillofacial Surgeons
- Ornamental Nursery, Crystal River
- Ornamental Nursery Services, Crystal River
- Orthodontist, Crystal River - Teeth Straightening, Invisalign & Dental Braces
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- Orthopedic & Prosthetic Appliances & Shoes, Crystal River - Orthopedic Shoes
- Orthopedists, Crystal River - Orthopedic Surgery Doctors, Physicians & Surgeons
- Osteoporosis Doctors, Crystal River - Physicians & Surgeons
- Other Attorneys & Lawyers, Crystal River
- Other Attorneys & Lawyers, Crystal River
- Other Building Materials & Supplies, Crystal River
- Other Lawyers & Attorneys, Crystal River
- Other Lodging, Crystal River
- Outboard Motors, Crystal River
- Outboard Motors Parts & Repair, Crystal River
- Outdoor & Lawn & Garden Equipment Repair & Service, Crystal River
- Outdoor Equipment & Accessories, Crystal River
- Outdoor Furniture & Patio Furniture, Crystal River - Garden Furniture Stores
- Outpatient Services, Crystal River - Outpatient Care
- Oxygen & Respiratory Equipment & Supplies, Crystal River - Oxygen Concentrator, Tank, Machine, etc
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